thioetherlinked
Thioetherlinked refers to a molecule in which two carbon-containing fragments are joined by a thioether bridge, typically written as R–S–R'. The thioether linkage consists of a sulfur atom bound to two carbon atoms and is analogous to an ether, with sulfur replacing oxygen.
The C–S–C motif is flexible and relatively nonpolar, contributing conformational mobility to the molecule. Thioethers are
Natural and synthetic uses of thioether linkages are common. In bioconjugates and medicinal chemistry, thioether linkers
Synthesis of thioether bonds typically proceeds via nucleophilic substitution of a thiolate on an alkyl halide
Overall, thioetherlinked architectures are valued for their chemical stability, flexibility, and utility as linkers in a