tetracyclinelike
Tetracyclinelike describes chemical entities that resemble tetracycline in core structure and, often, in their biological activity. These compounds typically share a tetracyclic naphthacene ring system—four fused rings—with polar substituents such as hydroxyl, ketone, and amide groups. The arrangement of these features supports metal ion coordination and interactions with biological targets, most commonly related to protein synthesis.
Structural features of tetracyclinelike molecules are characterized by their rigid polycyclic core and varying substitutions that
Mechanistically, many tetracyclinelike compounds act by inhibiting bacterial protein synthesis. They bind to the 30S ribosomal
Resistance to tetracyclinelike agents often involves efflux pumps that remove the drug from the cell or ribosomal