tTregs
Thymus-derived regulatory T cells (tTregs) are a subset of CD4+ regulatory T cells that develop in the thymus and contribute to immune tolerance by limiting self-reactive responses and preventing autoimmunity. They express the transcription factor Foxp3 and the surface marker CD25, among other features.
Origin and markers. tTregs arise when developing thymocytes with intermediate affinity for self-antigens commit to the
Functions and mechanisms. tTregs suppress immune responses through cell-contact–dependent and cytokine-mediated pathways. Key mediators include CTLA-4,
Clinical relevance. tTregs are implicated in autoimmunity when their number or function is impaired. They are
Relation to other Tregs. tTregs are often contrasted with peripherally induced Tregs (pTregs or iTregs) that