sumoylaatio
Sumoylaatio, also known as small ubiquitin-like modifier (SUMO)ylation, is a post-translational modification process in eukaryotic cells where the SUMO protein is covalently attached to target proteins. This modification plays a crucial role in regulating various cellular functions, including DNA repair, gene expression, protein stability, and signal transduction. SUMO proteins belong to the ubiquitin-like modifier family, sharing structural similarities with ubiquitin but differing in their biological functions and target specificity.
The process of sumoylaatio involves a series of enzymatic steps analogous to ubiquitination. First, SUMO is
Sumoylaatio can be reversed by SUMO-specific proteases, such as SENP1, SENP2, and SENP5, which cleave SUMO from
Abnormal sumoylaatio has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Dysregulation