sulfenyyli
Sulfenyl (Finnish: sulfenyyli) is a functional group characterized by a single covalent bond between a sulfur atom and an organic substituent, typically represented as –S–. The group can be viewed as the sulfur analogue of the alcohol functional group, but unlike the hydroxyl group, it does not contain an oxygen atom and therefore exhibits distinct chemical properties. In organic synthesis, the sulfenyl group is usually introduced through sulfenyl halides (RSX, where X is a halogen) or through the coupling of thiols with radical initiators.
The simplest sulfenyl compound, hydrogen sulfide (H₂S), contains a sulfenyl group attached to two hydrogen atoms.
In medicinal chemistry, sulfenylating agents are used to modify proteins, creating transient disulfide bridges that can
While sulfenyl chemistry offers many functional advantages, its reactivity often necessitates careful control of reaction conditions,