sulfamate
Sulfamate is a term used for compounds that contain the sulfamate functional group, derived from sulfamic acid (NH2SO3H). In this context, sulfamates can be either salts formed with a counterion (often a metal or organic cation) or esters in which the hydrogen of the sulfonic group is replaced by an alkyl or aryl group. The common ester family includes alkyl sulfamates with the general structure RO-SO2-NH2, sometimes referred to as sulfamate esters.
- Sulfamate esters: RO-SO2-NH2, where R is an alkyl or aryl substituent.
- Sulfamate salts: formed when sulfamic acid or its derivatives pair with a cation such as Na+, K+,
- The sulfamate group is related to sulfamic acid, but the hydrogen on the sulfonic acid can be
- Sulfamate esters are commonly prepared by reacting sulfamic acid with alcohols in the presence of an
- Alternative routes include formation of sulfamoyl chlorides or related intermediates followed by reaction with alcohols or
- Sulfamate esters and sulfamate-containing salts are used as intermediates in organic synthesis and can serve as
- The sulfamate moiety appears in medicinal chemistry; sulfamate-containing compounds are studied as carbonic anhydrase inhibitors and
- In coordination chemistry, sulfamate ligands can bind metal centers and form various complex structures.
- Sulfamate compounds vary in solubility and stability; sulfamic acid derivatives are generally handled with standard chemical-safety