stromelysiner
Stromelysiner are a subgroup within the matrix metalloproteinases (MMPs) that specialize in the degradation and remodeling of the extracellular matrix. The best characterized members are stromelysin-1 and stromelysin-2. Like other MMPs, they are zinc-dependent endopeptidases secreted as inactive proenzymes and activated by proteolytic processing.
They share a modular structure that includes a catalytic domain containing a zinc ion and a hemopexin-like
Their substrates include proteoglycans, laminin, fibronectin, and non-fibrillar collagens, supporting cell migration, tissue remodeling, and wound
Stromelysiner are produced by several cell types, including fibroblasts, macrophages, and epithelial cells. Their expression is
Physiological roles encompass normal development, angiogenesis, and connective tissue remodeling during healing. Pathologically, dysregulated stromelysin activity
Research and therapeutic interest focus on modulating stromelysin activity to control matrix remodeling. Clinical applications have