signalsubstansinducerad

Signalsubstansinducerad is a term used to describe cellular processes in which the binding of a signaling molecule (a signal) to its receptor triggers the production, release, or upregulation of a secondary signaling substance (substans). The concept emphasizes how an initial signal can induce another mediator that propagates or modulates a biological response, creating cascading or amplifying effects within a cell, tissue, or organism. The term is commonly found in Swedish-language literature and may be translated as signal-substance-induced signaling.

Mechanisms and contexts. Upon receptor activation, intracellular signaling pathways (such as MAPK, PI3K/AKT, or calcium signaling) are engaged, leading to transcriptional or translational upregulation of genes encoding signaling substances. These induced substances can be cytokines, growth factors, prostaglandins, neuropeptides, or other mediators. The induced mediator can act autocrine (on the same cell), paracrine (on neighboring cells), or endocrine (systemically). This mechanism allows cells to coordinate complex responses to stimuli, adapt to changing conditions, and regulate processes such as inflammation, development, or tissue repair.

Relevance and implications. Understanding signalsubstansinducerad helps illuminate how primary signaling events translate into broader biological effects and how feedback and cross-talk shape outcomes. In medicine, targeting the induction step or the downstream mediators offers strategies for treating inflammatory diseases, cancer, autoimmune disorders, and neurological conditions.

Relation to related concepts. It is related to, but distinct from, core signal transduction and second-messenger concepts; it specifically highlights the inducible production of a signaling substance as part of the signaling cascade.

See also: cell signaling, cytokine signaling, autocrine signaling, paracrine signaling, endocrine signaling.