sPLA2IIB

sPLA2IIB, also known as group IIB secretory phospholipase A2, is a member of the phospholipase A2 (PLA2) enzyme family. PLA2 enzymes are involved in the hydrolysis of phospholipids, specifically the cleavage of the acyl bond at the sn-2 position of glycerophospholipids, releasing fatty acids and lysophospholipids. sPLA2IIB is a calcium-dependent enzyme that is primarily expressed in inflammatory cells, such as neutrophils and macrophages, as well as in various other cell types. It plays a crucial role in the inflammatory response by mediating the release of arachidonic acid, a precursor to pro-inflammatory eicosanoids. sPLA2IIB is also involved in the regulation of cell proliferation, differentiation, and apoptosis. The enzyme is encoded by the PLA2G2A gene and is regulated by various factors, including calcium, arachidonic acid, and certain cytokines. Dysregulation of sPLA2IIB has been implicated in various inflammatory and autoimmune diseases, making it an attractive target for therapeutic intervention.