rs2032582

rs2032582 is a coding single nucleotide polymorphism in the ABCB1 gene, also known as MDR1, which encodes the P-glycoprotein transporter. The variant is located in exon 21 at c.2677G>T/A and is considered tri-allelic, with the possible nucleotides G, T, or A. The G allele corresponds to the amino acid alanine (Ala) at position 893, while the T and A substitutions can yield Serine (Ser) or Threonine (Thr), respectively, altering the protein sequence (Ala893Ser or Ala893Thr).

The ABCB1 gene products, P-glycoprotein, function as an efflux transporter that affects the absorption, distribution, and elimination of many drugs and xenobiotics. Because rs2032582 changes the amino acid sequence of P-glycoprotein, it has been studied for possible effects on transporter activity, substrate specificity, or expression levels. However, findings across studies are inconsistent, and functional consequences remain uncertain for many drugs.

rs2032582 has been investigated in pharmacogenetic research of varied medications, including cardiovascular drugs (such as digoxin), immunosuppressants (e.g., cyclosporine, tacrolimus), protease inhibitors, antidepressants, and anticancer agents. While some studies report associations with altered drug plasma concentrations or response, others do not, and no universal clinical guidance relies on this SNP alone.

Allele frequencies for rs2032582 vary by ancestry, with different populations showing differing prevalences of the G, T, and A alleles. In practice, rs2032582 is often considered alongside other ABCB1 variants in haplotype analyses to explore potential cumulative effects on drug pharmacokinetics.