rho13

Rho13 is a variant of the Rho family of GTPases, a subgroup of the Ras superfamily of small signaling G proteins. These proteins are involved in various cellular processes, including cytoskeletal dynamics, cell migration, proliferation, and gene expression. Rho13, in particular, is less well characterized than other members such as RhoA, Rac1, and Cdc42, but it is believed to play a role in modulating actin organization and cellular motility.

The Rho family GTPases function as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. They are activated by Guanine nucleotide Exchange Factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). Once active, Rho13 interacts with various downstream effectors to influence cellular architecture.

Research on Rho13 is ongoing, and its specific functions, interaction partners, and signaling pathways are still being elucidated. Some studies suggest that Rho13 may have roles in neuronal development and cellular signaling pathways related to cancer and other diseases, but comprehensive functional data remains limited.

Due to its emerging status in cellular biology, Rho13 is often studied in the context of broader Rho GTPase research, providing insights into mechanisms of cell movement and organization. Understanding its precise contribution could have implications in developmental biology, neurobiology, and pathology, especially in processes involving abnormal cell migration and cytoskeletal reorganization.