relaxin1related

Relaxin1related refers to genes and proteins that are related to relaxin-1, a member of the relaxin/insulin-like peptide hormone family. The term is used to describe a set of peptide products and their gene families that share sequence similarity, structural features, and evolutionary origin with relaxin-1.

Overview

Rel atin family peptides are typically small secreted proteins that are produced as larger precursor propeptides and later processed to mature hormones. Members of this broader family often exhibit the characteristic insulin-like fold, including disulfide-bonded A- and B-chains. Relaxin1-related peptides show diversity in expression patterns across tissues and species, reflecting lineage-specific duplication and divergence.

Genes and evolution

The relaxin1related group includes RLN1 and related peptides across different mammals and other vertebrates. These genes often exist in clusters and have arisen through gene duplication events followed by sequence diversification. Comparative genomics reveals both conserved and species-specific features that shape receptor interactions and physiological roles.

Receptors and signaling

Peptides in the relaxin1related category typically signal through the relaxin family peptide receptors RXFP1–RXFP4. Receptor selection and tissue distribution influence the downstream effects, which can include remodeling of reproductive tissues, vascular function, and neuroendocrine regulation.

Expression and function

Relaxin1-related peptides are found in various tissues, including reproductive organs and the brain, with roles that span reproductive physiology, cardiovascular dynamics, and development. In some species, specific family members contribute to maternal tissue remodeling during pregnancy.

Clinical and research notes

Dysregulation of relaxin signaling has been studied in pregnancy-associated conditions and fibrosis. Relaxin1related peptides remain an area of active research for understanding evolution, receptor biology, and potential therapeutic applications.

See also

Relaxin-1, relaxin family peptide receptors (RXFP1–RXFP4), RLN2, RLN3.