referencegenome
A reference genome is a digital sequence that serves as a standard or baseline for a species’ genomic DNA. It provides a common coordinate system and annotation framework for aligning sequencing reads, identifying variants, and interpreting gene structure and function. A reference is not the genome of a single individual; it is typically a mosaic assembled from multiple individuals, with additional sequences sometimes derived from specialized cell lines or long-read data.
Construction and maintenance of a reference genome involve assembling and scaffolding reads into a contiguous sequence,
Uses of a reference genome include guiding read alignment, variant discovery and genotyping, and functional annotation