rapamycinbased
Rapamycin-based refers to therapies and research approaches that rely on rapamycin or related compounds to modulate the mammalian target of rapamycin (mTOR) signaling pathway. This pathway is a central regulator of cell growth, metabolism, and proliferation, and its inhibition can affect multiple cellular processes.
Mechanism and scope: Rapamycin forms a complex with FKBP12, and this complex inhibits mTOR complex 1 (mTORC1),
Clinical uses: Rapamycin-based therapies are used as immunosuppressants to prevent organ transplant rejection and as anticancer
Safety and limitations: Common adverse effects include mouth ulcers, edema, hyperlipidemia, hyperglycemia, cytopenias, and increased infection