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Pyridoxal phosphate, often abbreviated as PLP, is the active coenzyme form of vitamin B6. It plays a crucial role in a wide variety of biochemical reactions within living organisms, particularly in the metabolism of amino acids. PLP acts as a cofactor for over 140 enzymes, participating in reactions such as transamination, decarboxylation, and racemization. These enzymatic processes are essential for the synthesis and breakdown of amino acids, which are the building blocks of proteins.
The structure of pyridoxal phosphate consists of a pyridoxine ring, a phosphate group, and an aldehyde group.
In humans, pyridoxal phosphate is vital for neurotransmitter synthesis, including serotonin and dopamine, as well as