püridoksal5fosfaat

Pyridoxal 5 phosphate, often abbreviated as PLP, is the active coenzyme form of vitamin B6. Vitamin B6 itself is a group of related compounds that includes pyridoxine, pyridoxal, and pyridoxamine, along with their phosphorylated derivatives. PLP is crucial for a wide range of metabolic processes within the body, playing a vital role as a cofactor in over 140 enzymatic reactions.

These enzymatic reactions primarily involve amino acid metabolism. PLP is essential for processes such as transamination, deamination, decarboxylation, and racemization of amino acids. This makes it fundamental for protein synthesis and breakdown, as well as the production of neurotransmitters like serotonin, dopamine, and GABA. It is also involved in the synthesis of heme, a component of hemoglobin, and in the metabolism of carbohydrates and lipids.

The body obtains vitamin B6 from dietary sources such as meat, fish, poultry, legumes, nuts, and fortified cereals. Once ingested, these forms are converted to pyridoxal 5 phosphate in the liver. Deficiency in vitamin B6 can lead to a variety of health issues, including neurological problems, skin disorders, and anemia. However, PLP is generally well-tolerated, and excessive intake is rare from food sources.