pyridine3carboxamide

Pyridine-3-carboxamide, commonly known as nicotinamide or 3-pyridinamide, is an organic compound with the formula C6H6N2O. It is the amide derivative of nicotinic acid (pyridine-3-carboxylic acid) and the simplest amide form of niacin, the vitamin B3.

Chemically, the molecule consists of a pyridine ring bearing a carboxamide group at the 3-position. The ring contains a basic nitrogen atom, while the amide functionality contributes to the compound’s overall reactivity. Nicotinamide is typically encountered as a white crystalline solid and is soluble in water and many polar organic solvents.

Biologically and nutritionally, nicotinamide is the water-soluble form of vitamin B3 and an important precursor to the redox cofactors NAD+ and NADP+. In cells, nicotinamide can be salvaged and converted into nicotinamide adenine dinucleotide (NAD+) via established metabolic pathways, supporting energy metabolism and various biosynthetic processes. It can be obtained from the diet or produced endogenously from niacin.

In addition to its role as a vitamin, nicotinamide is used as a pharmaceutical intermediate and a research reagent. It serves as a building block in organic synthesis for pyridine-containing compounds and is used in some cosmetic formulations for skin-related applications. Nicotinamide is often preferred over nicotinic acid in supplements because it does not induce flushing.

Safety and regulation: nicotinamide is generally well tolerated at typical dietary supplement doses. As with other chemicals, it should be handled and used in accordance with applicable safety guidelines and regulatory requirements.