protrombinem
Protrombinem is the instrumental case in Polish medical terminology for protrombin, known in English as prothrombin. Prothrombin is a vitamin K–dependent plasma glycoprotein and one of the coagulation factor proteins designated as factor II. It is produced by hepatocytes as a single, inactive zymogen and serves as the precursor to thrombin, a key enzyme in blood coagulation.
Prothrombin contains a gamma-carboxyglutamate (Gla)–rich N-terminal domain that requires vitamin K–dependent carboxylation, two kringle domains, and
Prothrombin is activated to thrombin by the prothrombinase complex, formed by factor Xa and factor Va on
Abnormal prothrombin levels or function can lead to bleeding disorders or thrombotic tendencies. Hereditary prothrombin deficiencies