prometa

Prometa is a proprietary detoxification and addiction treatment protocol marketed as an adjunct to conventional therapy. Introduced in the late 2000s by a private company, it is offered at outpatient clinics to aid recovery from various substance use disorders. Proponents claim it reduces withdrawal symptoms and cravings by enhancing liver and brain detoxification.

Typical regimens involve intravenous infusions containing glutathione and B vitamins, often with niacin, and some versions include NAD+. The exact formulation and dosing are proprietary and vary by provider. Treatments are usually combined with counseling and standard addiction treatment approaches.

Prometa is not approved by major regulators such as the U.S. Food and Drug Administration for addiction treatment. The existing evidence base consists mainly of small, uncontrolled studies, case reports, and practitioner testimonials; rigorous, large-scale trials showing clear benefit are lacking. Critics note the limited independent verification of claims, the high cost, and risks associated with intravenous therapy.

Safety considerations include niacin-related flushing and warmth, infusion reactions, and risks associated with IV procedures. Clinicians should ensure informed consent, assess potential interactions with other medications, and consider the lack of robust evidence when discussing Prometa with patients. Some patients report short-term improvements, but the overall clinical effectiveness remains uncertain and controversial within the medical community.