preadipocyt

Preadipocytes are undifferentiated cells that have the potential to develop into mature adipocytes, commonly known as fat cells. These precursor cells are a crucial component of adipose tissue development and maintenance. Preadipocytes can be found in various locations throughout the body, including bone marrow, the stromal vascular fraction of adipose tissue, and skeletal muscle.

The process of differentiation from a preadipocyte to an adipocyte is known as adipogenesis. This is a complex process regulated by a cascade of transcription factors and signaling pathways. During adipogenesis, preadipocytes undergo significant morphological and biochemical changes. They increase in size, accumulate lipid droplets, and begin to express specific adipocyte markers, such as fatty acid binding protein 4 (FABP4) and adiponectin.

The number and activity of preadipocytes play a role in regulating body fat mass. An increased proliferation or reduced differentiation of preadipocytes can contribute to obesity, while an adequate supply of functional preadipocytes is important for healthy energy storage and metabolic function. Research into preadipocytes is ongoing, aiming to understand their role in metabolic disorders and to explore potential therapeutic targets for conditions like obesity and diabetes.