polyanhydrides

Polyanhydrides are a class of polymers characterized by anhydride linkages in their backbone. These linkages, consisting of two carbonyl groups connected to an oxygen atom (R-CO-O-CO-R'), are susceptible to hydrolysis, making polyanhydrides biodegradable and bioresorbable materials. The degradation products are typically carboxylic acids, which can be further metabolized or excreted.

The synthesis of polyanhydrides usually involves the polycondensation of dicarboxylic acids or their derivatives. Common methods include the melt polycondensation of dicarboxylic acids with a dehydrating agent or the interfacial polymerization of dicarboxylic acid chlorides. The properties of polyanhydrides can be tailored by varying the monomers used. This allows for control over their degradation rate, mechanical properties, and drug-release profiles.

Polyanhydrides have garnered significant interest for biomedical applications, particularly in drug delivery systems. Their ability to degrade in aqueous environments and release encapsulated therapeutic agents at a controlled rate makes them ideal for sustained drug release. They have been explored for delivering a wide range of drugs, including anti-cancer agents, hormones, and proteins. The degradation products are generally biocompatible, minimizing adverse tissue reactions. Beyond drug delivery, polyanhydrides are also investigated for use in tissue engineering scaffolds and biodegradable implants.