poly3HB

Poly(3-hydroxybutyrate), often abbreviated as P3HB, is a naturally occurring polyester produced by numerous microorganisms as a way to store carbon and energy reserves. It belongs to the larger family of polyhydroxyalkanoates (PHAs), which are biodegradable and biocompatible polyesters. P3HB is synthesized intracellularly by bacteria when nutrients are abundant but growth is limited. Under nutrient-depleted conditions, the bacteria can depolymerize P3HB to obtain energy.

The chemical structure of P3HB consists of repeating units of 3-hydroxybutyric acid linked by ester bonds. This specific arrangement of monomers gives P3HB its characteristic properties. It is a thermoplastic material that exhibits a semi-crystalline structure. P3HB is known for its biodegradability, breaking down in the environment through microbial action, which makes it an attractive alternative to conventional petroleum-based plastics. It also possesses good mechanical properties, including a relatively high tensile strength, although it can be brittle.

Research into P3HB has focused on its potential applications in various fields. Its biocompatibility and biodegradability make it suitable for medical devices such as sutures, tissue scaffolds, and drug delivery systems. Furthermore, its environmental friendliness has led to investigations into its use as a sustainable packaging material and in other disposable plastic applications. The production of P3HB is typically achieved through fermentation processes using selected bacterial strains, and ongoing efforts aim to improve yields and reduce production costs to enable wider commercialization.