peripheralproteiinit
Peripheralproteiinit is a proposed category of proteins that attach to the cytoplasmic face of cellular membranes without spanning the bilayer. Members are defined by their peripheral association and their apparent role in initiating signaling or assembly of molecular complexes at membrane surfaces.
Localization and interactions: They associate via post-translational lipid modifications (such as myristoylation, palmitoylation, or prenylation) or
Function: They act as initiators by concentrating receptors, kinases, and adaptor proteins into membrane microdomains, thereby
Evidence and examples: In current studies, PPIN-1 and PPIN-2 are cited as prototypical peripheralproteiinit in certain
Status and outlook: The concept remains under investigation, and some researchers describe peripheralproteiinit as dynamic organizers