paracetamolmérgezésre

Paracetamolmérgezésre refers to the toxic effects that can occur when a person takes an excessive dose of paracetamol, also known as acetaminophen. Paracetamol is a common over-the-counter pain reliever and fever reducer found in many medications. While generally safe at recommended doses, exceeding the maximum daily intake can lead to serious liver damage.

The liver is responsible for metabolizing paracetamol. When too much is ingested, the normal metabolic pathways become saturated, and a toxic byproduct, NAPQI, accumulates. This byproduct can cause damage to liver cells, leading to a condition called acute liver failure. Symptoms of paracetamol poisoning may not appear immediately. Early signs can include nausea, vomiting, abdominal pain, and general malaise, often occurring 24 to 48 hours after ingestion. As liver damage progresses, more severe symptoms like jaundice (yellowing of the skin and eyes), confusion, and even coma can develop.

The severity of the poisoning depends on the amount ingested and the time elapsed since ingestion. Prompt medical attention is crucial for anyone suspected of paracetamol overdose. Treatment typically involves administering an antidote, N-acetylcysteine (NAC), which helps the liver process the toxic byproduct and prevent further damage. NAC is most effective when given within 8 to 10 hours of the overdose. In cases of severe liver damage, a liver transplant may be necessary. It is essential to always follow the recommended dosage instructions on medication packaging or consult a healthcare professional to avoid accidental overdose.