pS473

pS473 is a phosphorylation site found on various proteins, including those involved in cell signaling, transcription, and cell cycle regulation. It is a serine residue at position 473 within a protein sequence, which can be modified by the addition of a phosphate group through the action of kinases. This post-translational modification can alter the protein's structure, stability, and function, often leading to changes in cellular processes.

The pS473 site is particularly notable in the context of the p53 protein, a tumor suppressor that plays a crucial role in cellular responses to stress, DNA damage, and oncogene activation. Phosphorylation at this site can regulate p53's activity, affecting its ability to bind to DNA and regulate gene expression. This regulation is important for maintaining genomic stability and preventing cancer.

In addition to p53, pS473 is found in other proteins, such as those involved in the Wnt signaling pathway and the regulation of cell cycle progression. The specific functions and regulatory mechanisms of pS473 vary depending on the protein in which it is found, highlighting its importance in diverse cellular processes.

The study of pS473 and its role in protein function is an active area of research, with ongoing investigations into its regulatory mechanisms and potential as a therapeutic target in various diseases. Understanding the function of pS473 and its impact on protein activity is essential for advancing our knowledge of cellular regulation and developing new strategies for treating diseases associated with altered protein function.