ortólogos

Ortólogos is a term occasionally used in biology to denote researchers who study orthology, a concept in comparative genomics describing gene relationships across species that originated by speciation events. An ortólogo refers to a gene in different species that descended from a single ancestral gene through speciation, as opposed to paralogs, which arise by gene duplication within a lineage. The word is not uniformly used in all Spanish-language literature; more common expressions include investigador en ortología or científico de genómica evolutiva.

Ortólogos typically work in genomics, evolutionary biology, and bioinformatics. Their activities include developing and applying computational methods to detect orthologs, constructing orthologous gene maps, analyzing gene families, and studying patterns of genome evolution. They employ phylogenetic analysis, synteny information, and sequence similarity to establish relationships among genes across diverse organisms. Practical applications of orthology include transferring functional annotations between species, reconstructing ancestral gene repertoires, and informing phylogenomic studies and cross-species comparisons.

Education and training for a career as an ortólogo usually involve advanced degrees in biology, bioinformatics, or computational biology, with emphasis on sequence analysis, phylogenetics, and programming. The field intersects with related disciplines such as comparative genomics, phylogenomics, and evolutionary systems biology.

History and usage: the concept of orthology was formalized in the context of gene evolution in the 1970s, with the term orthology gaining prominence alongside the expansion of genome sequencing in the 1990s and beyond. In Spanish, the term ortólogo appears variably in literature, with many authors preferring broader phrases like “investigador de ortología” or “científico de genómica evolutiva.”

See also: orthology, paralogy, comparative genomics, phylogenomics.