orbitome

The orbitome is a concept in molecular biology that refers to the collection of all possible RNA secondary structures that can be formed by a given RNA sequence. It encompasses every possible folding pattern that the RNA molecule can adopt, considering the constraints imposed by base pairing rules and the sequence itself. The term was introduced to provide a comprehensive framework for understanding the structural diversity and functional potential of RNA molecules.

The orbitome is particularly relevant in the study of non-coding RNAs, which play crucial roles in various biological processes such as gene regulation, protein synthesis, and cellular communication. By exploring the orbitome, researchers can identify stable and functional RNA structures that may have biological significance. This approach is complementary to traditional methods that focus on individual RNA structures or specific folding algorithms.

The concept of the orbitome highlights the importance of considering the entire landscape of possible RNA structures rather than just a single or a few predicted structures. This holistic view can lead to a deeper understanding of RNA function and the development of new therapeutic strategies targeting RNA-based diseases.

In summary, the orbitome represents a powerful tool in RNA research, offering insights into the structural and functional diversity of RNA molecules. By mapping out the orbitome, scientists can uncover hidden structural motifs and functional elements that contribute to the complex regulatory networks within cells.