néovascularisations

Neovascularisation, also known as angiogenesis, is the physiological process through which new blood vessels form from pre-existing ones. This is a crucial process for growth and development, as well as for wound healing and the formation of granulation tissue. In healthy individuals, neovascularisation is tightly regulated, with a balance between pro-angiogenic and anti-angiogenic factors.

However, abnormal neovascularisation is implicated in a variety of pathological conditions. In diseases like cancer, tumors can induce neovascularisation to supply themselves with the oxygen and nutrients they need to grow and metastasize. This tumor-induced angiogenesis is a key target for anti-cancer therapies.

Neovascularisation also plays a significant role in eye diseases such as diabetic retinopathy and age-related macular degeneration. In these conditions, abnormal blood vessels can grow in the retina, leading to leakage, bleeding, and vision loss. Treatments for these conditions often aim to inhibit this aberrant neovascularisation.

Conversely, impaired neovascularisation can be problematic. For example, insufficient blood supply due to poor angiogenesis can hinder wound healing or lead to conditions like peripheral artery disease. Therapeutic strategies are being developed to promote neovascularisation in such cases, aiming to restore adequate blood flow. The study of neovascularisation is an active area of research with significant implications for understanding and treating a wide range of diseases.