nichtIgEabhängige

nichtIgEabhängige refers to a category of adverse food reactions that are not mediated by immunoglobulin E (IgE) antibodies. Unlike IgE-mediated allergies, which typically manifest with rapid onset symptoms such as hives, swelling, or anaphylaxis, non-IgE-mediated reactions often have delayed and more variable presentations. These reactions can affect various parts of the gastrointestinal tract and sometimes the skin.

Common examples of non-IgE-mediated food reactions include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy, and food protein-induced proctocolitis. FPIES is characterized by profuse vomiting, diarrhea, and sometimes lethargy or paleness, typically occurring several hours after ingesting the trigger food. Enteropathy can lead to chronic diarrhea, poor weight gain, and malabsorption. Proctocolitis is most often seen in infants and presents with blood and mucus in the stool.

The diagnosis of non-IgE-mediated food reactions can be challenging due to the absence of specific IgE tests and the overlap of symptoms with other conditions. Diagnosis often relies on a thorough medical history, elimination diets, and oral food challenges under medical supervision to confirm the suspected food as the cause of the symptoms. Management typically involves the strict avoidance of the offending food. The underlying mechanisms of these reactions are diverse and may involve other immune cells and pathways, distinguishing them clearly from classic IgE-mediated allergies.