neonatalalloimmuunihemoliosta
Neonatal alloimmune hemolysis is a condition in which maternal IgG antibodies directed against fetal red blood cell antigens cross the placenta and cause destruction of fetal or newborn red blood cells. It most commonly arises from incompatibilities such as Rh(D) but other antigens, including Kell, Duffy, Kidd, E and c, can be involved. It is a form of hemolytic disease of the fetus and newborn.
The underlying mechanism involves maternal exposure to fetal red cell antigens, which leads to the production
Clinical features vary from fetal anemia and hydrops to postnatal jaundice and anemia. In the newborn, signs
Diagnosis relies on maternal antibody screening and identification of specific alloantibodies, along with testing of the
Prevention involves RhD immune prophylaxis for Rh-negative mothers and routine prenatal antibody screening to detect clinically