mucoussecreting

Mucoussecreting (also written mucous-secreting) refers to cells and tissues that produce mucus, a viscous secretory gel composed mainly of water, ions, and mucins, which are large glycoproteins.

The primary producers are goblet cells in the lining of the respiratory and gastrointestinal tracts, and submucosal glands in the airways and certain mucosal surfaces.

Mucins such as MUC5AC, MUC5B in airways, and MUC2 in the intestine form the gel matrix; their glycosylation and hydration determine mucus viscosity and elasticity.

Functions include lubrication, protection against mechanical and chemical injury, trapping of particulates and pathogens, and participation in local immune defense.

Secretion is regulated by neural and hormonal signals, microbial and inflammatory cues, and hydration status; acetylcholine and other secretagogues stimulate goblet and gland activity.

Clinical relevance: abnormal mucous secretion is seen in chronic bronchitis, asthma, and cystic fibrosis; reduced secretion contributes to dry mucous membranes in Sjögren-like conditions.

Understanding mucoussecreting is important for studies of mucosal protection, airway clearance, and disease progression, with ongoing research into mucin gene regulation and mucin-based therapies.