microtubuledependent
Microtubule-dependent describes cellular processes that require microtubules, the cylindrical polymers composed of tubulin that form a major part of the cytoskeleton. Microtubules provide structural support and create organized networks that act as tracks for molecular motors, enabling directed movement of organelles, vesicles, and protein complexes within eukaryotic cells. They are dynamic, undergoing phases of growth and shrinkage (dynamic instability), which helps regulate transport routes and force generation.
Motor proteins such as kinesin and dynein drive most microtubule-dependent transport. Kinesins usually move cargo toward
In cell division, microtubule-dependent mechanisms organize the mitotic spindle, align chromosomes, and segregate sister chromatids. Microtubules
Other contexts of microtubule dependence include intraflagellar transport within cilia and flagella, and long-range axonal transport
Clinically, defects in microtubule dynamics or motor proteins can contribute to neurodevelopmental and neurodegenerative disorders. Pharmacological