metastasissuppressing
Metastasissuppressing refers to mechanisms, genes, and therapeutic strategies that reduce the likelihood that cancer cells will spread from a primary tumor to distant sites. It is distinct from general tumor suppression, which aims to control local growth; metastasis suppression specifically targets steps of the metastatic cascade, including invasion, intravasation, survival in the circulation, extravasation, and colonization.
Metastasis suppressor genes (MSGs) are a defined class of genes whose expression inhibits metastasis without necessarily
Therapeutic implications focus on restoring or enhancing MSG activity, or targeting downstream pathways to mimic metastasis
Clinically, MSG expression levels can serve as prognostic markers in some cancers, helping assess metastatic risk.