mAChRs
mAChRs, or muscarinic acetylcholine receptors, are a class of G protein-coupled receptors (GPCRs) that are activated by the neurotransmitter acetylcholine. These receptors play a crucial role in the parasympathetic nervous system, mediating various physiological responses including modulation of heart rate, smooth muscle contraction, glandular secretion, and cognitive functions.
There are five subtypes of mAChRs, labeled M1 through M5, each encoded by distinct genes and exhibiting
mAChRs are widely expressed throughout the body. For example, M2 receptors are predominant in cardiac tissue,
Pharmacologically, mAChRs are targeted by various drugs used to treat conditions like glaucoma, gastrointestinal disorders, and
Research on mAChRs continues to provide insights into their role in health and disease, including neurodegenerative