loratadiini
Loratadiini, the Italian name for loratadina, is a second-generation oral antihistamine used to relieve symptoms of allergic rhinitis, conjunctivitis, and chronic idiopathic urticaria. It acts as a selective antagonist of peripheral histamine H1 receptors, reducing sneezing, itching, runny nose, and hives. Compared with first-generation antihistamines, loratadina is designed to cause less drowsiness because it crosses the blood–brain barrier to a lesser extent.
Pharmacokinetics and metabolism: after oral administration, loratadina is rapidly absorbed and reaches peak plasma levels within
Formulations and dosing: available as tablets and rapidly disintegrating tablets for oral use, with dosing tailored
Safety and regulation: adverse effects are generally mild and may include headache, fatigue, dry mouth, or somnolence
History: loratadina was developed in the late 20th century and marketed under brand names such as Claritin;