ligandinin

Ligandin is a protein that plays a crucial role in the transport and metabolism of various endogenous and exogenous lipophilic compounds within cells. It is a member of the glutathione S-transferase (GST) family, specifically belonging to the GST Ya and GST Yb classes. Ligandin is found in high concentrations in the liver and is also present in other tissues such as the kidneys and intestines. Its primary function is to bind to a wide range of molecules, including bilirubin, bile acids, steroids, fatty acids, and certain drugs and carcinogens. This binding action facilitates the intracellular movement of these hydrophobic substances, preventing their aggregation and protecting cellular membranes. Furthermore, ligandin's association with GST enzymes allows it to catalyze the conjugation of certain xenobiotics with glutathione, a process that enhances their water solubility and promotes their excretion from the body. This detoxification function is vital for protecting cells from the harmful effects of toxic compounds. Ligandin is also implicated in other cellular processes, including cell proliferation and differentiation, although these roles are less well-understood. Its ability to interact with multiple cellular targets highlights its importance in maintaining cellular homeostasis and protecting against oxidative stress and toxic insults.