laktamaser
Laktamaser are a family of enzymes produced by many bacteria that hydrolyze the beta-lactam ring found in penicillins, cephalosporins, and related antibiotics. By breaking this chemical structure, laktamaser inactivate the drugs and enable bacterial survival in the presence of beta-lactam antibiotics. They are a primary mechanism of antibiotic resistance in clinical settings.
Beta-lactamases operate through two main catalytic strategies: serine-based hydrolysis and metal-dependent hydrolysis. Based on amino acid
Notable families and examples include TEM, SHV and CTX-M enzymes (Class A, many ESBLs), KPC and OXA-48-like
Detection typically combines phenotypic tests, such as nitrocefin-based assays, with molecular methods that identify specific beta-lactamase