kolestaatilised

Cholestasis is a condition characterized by the interruption of bile flow from the liver. Bile is a fluid produced by the liver that aids in digestion and the removal of waste products from the body. When bile flow is obstructed, bile pigments, particularly bilirubin, can accumulate in the blood and tissues, leading to symptoms such as jaundice, which is the yellowing of the skin and eyes.

Cholestasis can be caused by a variety of factors, broadly categorized as either intrahepatic (occurring within the liver) or extrahepatic (occurring outside the liver). Intrahepatic causes include certain medications, viral hepatitis, autoimmune diseases affecting the liver, and genetic disorders. Extrahepatic causes typically involve mechanical obstruction of the bile ducts, such as gallstones, tumors in or near the bile ducts, or inflammation of the bile ducts (cholangitis).

Symptoms of cholestasis can vary depending on the underlying cause and severity. In addition to jaundice, individuals may experience itching (pruritus), pale stools, dark urine, abdominal pain, and fatigue. Persistent or severe cholestasis can lead to complications such as malabsorption of fat-soluble vitamins (A, D, E, and K), bone disease, and liver damage. Diagnosis often involves blood tests to check liver function and bilirubin levels, imaging studies like ultrasound or MRI, and sometimes a liver biopsy. Treatment aims to address the underlying cause and manage symptoms.