keratiini14geenissä
The Keratin 14 gene, often referred to as KRT14, encodes a type II keratin protein. Keratins are a family of fibrous structural proteins that are a key component of the epidermis, hair, and nails in mammals. Specifically, Keratin 14 is a type II keratin that is typically expressed in the basal layer of stratified epithelial tissues. It is known to be highly abundant in epidermal stem cells and terminally differentiating keratinocytes.
The KRT14 gene plays a crucial role in maintaining the structural integrity of the epidermis. It heterodimerizes
Epidermolysis bullosa simplex (EBS) is a group of blistering skin disorders that can be caused by mutations