interstitiumiks

The interstitium is a network of interconnected, fluid-filled spaces within the body. Historically, it was often considered merely a passive space occupied by connective tissue. However, recent research has revealed it to be a dynamic and functionally significant compartment. It is found throughout the body, beneath the epithelial and endothelial linings of organs and tissues, and surrounding blood vessels and nerves.

The interstitium is comprised of a gel-like matrix composed of glycosaminoglycans, proteoglycans, and collagen fibers. Within this matrix, interstitial fluid flows, transporting nutrients, oxygen, and waste products. Specialized cells, such as fibroblasts and immune cells, also reside within the interstitial space, playing roles in tissue repair, defense, and maintaining the structural integrity of tissues.

The interstitial fluid is in constant motion, exchanging substances with blood capillaries and lymphatic vessels. This fluid circulation is crucial for maintaining cellular health and removing metabolic byproducts. The pressure within the interstitium, known as interstitial fluid pressure, is an important physiological parameter that influences fluid exchange and tissue function.

Dysregulation of the interstitium has been implicated in various diseases, including fibrosis, edema, and inflammation. Understanding the complex structure and function of the interstitium is an ongoing area of research with potential implications for developing new therapeutic strategies for a wide range of conditions.