hyperoxalurie
Hyperoxaluria is a condition characterized by abnormally high levels of oxalate excreted in the urine, which can promote the formation of calcium oxalate kidney stones and nephrocalcinosis. It is usually categorized as primary or secondary.
Primary hyperoxaluria refers to inherited disorders that cause overproduction of oxalate in the liver. The best
Pathophysiology involves oxalate binding calcium to form calcium oxalate crystals, which can accumulate in the kidneys,
Diagnosis relies on measurements of 24-hour urinary oxalate excretion, urinary oxalate-to-creatinine ratios, and stone analysis, with
Treatment focuses on reducing oxalate burden and preventing stones: high fluid intake, citrate to inhibit crystallization,