hemolysisindicating

Hemolysisindicating, or hemolysis-indicating, denotes markers or indicators that signal the breakdown of red blood cells (hemolysis). The term is used in laboratory medicine and clinical diagnostics to describe signs that hemolysis has occurred or is ongoing, whether in a test specimen or in the patient.

In the laboratory, several measurements provide a hemolysis indication. Automated analyzers report a hemolysis index or hemolysis level based on the color and absorbance of plasma or serum, often around 414 nm for free hemoglobin. A higher hemolysis index indicates greater red cell disruption and potential interference with assays. Laboratories may reject samples with excessive hemolysis or re-collect.

Biochemically, signs of hemolysis include elevated free plasma hemoglobin, decreased haptoglobin (which binds free Hb), increased lactate dehydrogenase (LDH), and rising indirect bilirubin. Urine may become hemoglobinuric in intravascular hemolysis. Peripheral blood smear can show schistocytes or fragmented cells in certain conditions, though not universally.

Hemolysisindicating markers have dual relevance: they help identify in vitro sample quality problems that compromise test accuracy, and they reflect underlying pathophysiology in diseases causing hemolysis. Correct interpretation requires considering sample handling, timing, and clinical context.