hAGT

The term "hAGT" refers to the human gene encoding the enzyme AGT, also known as angiotensinogen. Angiotensinogen is a precursor protein that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS). This system is a key regulator of blood pressure and fluid balance in the body.

The hAGT gene is primarily expressed in the liver, where it produces angiotensinogen. Once released into the bloodstream, angiotensinogen is cleaved by the enzyme renin to produce angiotensin I. Angiotensin I is then converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, which increases blood pressure. It also stimulates the release of aldosterone from the adrenal glands, which promotes sodium and water retention, further contributing to increased blood pressure.

Variations in the hAGT gene have been associated with an increased risk of developing hypertension and other cardiovascular diseases. Research has explored the impact of different hAGT gene polymorphisms on blood pressure regulation and the effectiveness of RAAS-targeting medications. Understanding the role of hAGT is important for comprehending the physiological mechanisms underlying blood pressure control and for identifying potential genetic predispositions to cardiovascular conditions.