glyukokinaasi
Glyukokinaasi, also known as glucokinase (GCK), is a cytosolic enzyme that catalyzes the ATP-dependent phosphorylation of glucose to glucose-6-phosphate, the first step in glycolysis and a key control point in glucose metabolism. It has a relatively high Km for glucose, meaning it acts when blood glucose is elevated, and it is not inhibited by glucose-6-phosphate, unlike other hexokinases.
Glyukokinaasi is predominantly expressed in the liver and pancreatic beta cells, with roles in both liver glucose
Regulation of glucokinase involves its interaction with the glucokinase regulatory protein (GKRP) in the liver. GKRP
Clinical significance includes genetic variations in the GCK gene. Inactivating mutations cause maturity-onset diabetes of the