firstinhuman

Firstinhuman is a term used in multiple contexts, most commonly as a stylized form of the phrase first-in-human. In biomedical research, the conventional spelling is first-in-human or FIH, but the single-word variant appears in some digital and branding contexts. The term broadly signals the initial stage at which a medical intervention is tested in humans, following preclinical work in the laboratory and in animal studies.

In clinical research, first-in-human trials are Phase I studies designed to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of a new drug, biologic, or medical device. These studies typically involve a small number of participants and may use dose-escalation to identify a safe starting dose and a maximum tolerated dose. Participants are chosen based on specific inclusion criteria, and the trials proceed under strict ethical oversight, including informed consent, institutional review board or ethics committee approval, and continuous safety monitoring. Results from FIH studies inform whether the intervention proceeds to later-phase trials, with risk-benefit considerations guiding progression.

In culture and media, the concept of “first in human” has been explored in science fiction and discussions of bioethics, often focusing on the social and moral implications of introducing a new intervention to people for the first time. The exact term firstinhuman may also be used as a username, brand name, or artistic alias, though it does not denote a single widely recognized entity.