fibrinogént

Fibrinogen is a protein produced by the liver that plays a crucial role in blood clotting. It is a soluble plasma protein that circulates in the bloodstream and is converted into an insoluble fibrin polymer during the clotting process. Fibrinogen is composed of three pairs of polypeptide chains: two alpha chains, one gamma chain, and one beta chain. This protein is essential for wound healing and tissue repair by forming a stable clot that stops bleeding.

The clotting process begins when fibrinogen is converted into fibrin by the enzyme thrombin, which is released by platelets during the initial stages of clotting. Fibrin then forms a mesh-like structure that traps red blood cells and other components, creating a stable clot. This clot helps to seal the site of injury and prevents further blood loss.

Fibrinogen levels in the blood are regulated by the liver and can be influenced by various factors, including liver disease, inflammation, and certain medications. Low levels of fibrinogen, known as hypofibrinogenemia, can lead to excessive bleeding, while high levels, known as hyperfibrinogenemia, can increase the risk of blood clots.

Fibrinogen is also a marker of inflammation and is often elevated in conditions such as rheumatoid arthritis, lupus, and other inflammatory diseases. It is measured in the blood as part of a complete blood count and is used to monitor various medical conditions and treatments.