epoprostenoli

Epoprostenol is a synthetic form of prostacyclin, a naturally occurring substance produced by cells lining blood vessel walls. It is a potent vasodilator, meaning it widens blood vessels, and also inhibits platelet aggregation, which is the clumping of blood cells that can lead to clots. Epoprostenol is administered intravenously and has a very short half-life, requiring continuous infusion.

Its primary medical use is in the treatment of pulmonary arterial hypertension (PAH), a serious condition characterized by high blood pressure in the arteries of the lungs. By dilating the pulmonary arteries, epoprostenol reduces the workload on the right side of the heart and improves symptoms such as shortness of breath and fatigue. It is typically reserved for patients with severe PAH who have not responded adequately to other therapies.

Due to its potent effects and the need for continuous intravenous administration, epoprostenol requires careful monitoring and management by healthcare professionals. Potential side effects can include flushing, headache, nausea, vomiting, diarrhea, and jaw pain. It is also important to manage potential infusion-related complications. The use of epoprostenol is a significant intervention and is usually initiated in specialized centers.