endosomallysosomal
Endosomallysosomal is a term used to describe the cellular system that encompasses endosomes and lysosomes, together with the pathways that connect them. It refers to the maturation, trafficking, and degradation of materials internalized by the cell, as well as the turnover of membrane and soluble components. The endosomallysosomal system functions as a central hub for nutrient sensing, signaling, and quality control.
Endosomes arise from endocytosis. Early endosomes act as sorting stations, retaining or recycling cargo; they mature
Key processes associated with the endosomallysosomal system include endocytosis, endosome maturation, lysosome biogenesis, autophagy, and phagosome-lysosome
Dysfunction of the endosomallysosomal axis is linked to human diseases, notably lysosomal storage disorders and neurodegenerative