eIF6

eIF6, also known as translation initiation factor 6, is a protein that plays a crucial role in the regulation of protein synthesis. It is a component of the 60S ribosomal subunit and is essential for the proper assembly of the 80S ribosome, the cellular machinery responsible for translating messenger RNA (mRNA) into proteins. eIF6 binds to the 60S subunit and prevents its premature association with the 40S ribosomal subunit, which is required for translation initiation. This inhibitory function ensures that translation initiation occurs only at the correct time and place.

The activity of eIF6 is tightly regulated by various signaling pathways, including those involving growth factors and stress. Its function is particularly important during cell growth and proliferation, where it helps to coordinate the demand for protein synthesis with cellular resources. Dysregulation of eIF6 has been implicated in various diseases, including cancer. In many cancers, eIF6 is overexpressed, contributing to uncontrolled cell growth and survival by promoting increased protein synthesis. Research is ongoing to understand the precise mechanisms by which eIF6 contributes to tumorigenesis and to explore its potential as a therapeutic target. Inhibiting eIF6 activity is being investigated as a strategy to suppress tumor growth.