druginadhesive
Drug-in-adhesive (DIA) refers to a formulation approach in transdermal drug delivery systems where the active pharmaceutical ingredient is dispersed within the pressure-sensitive adhesive that directly adheres to the skin. This design contrasts with reservoir or matrix systems that place the drug in a separate compartment or behind a rate-controlling layer.
Common adhesive chemistries for DIA include acrylate- and silicone-based pressure-sensitive adhesives. The drug is typically dissolved
The drug diffuses from the adhesive into the skin by diffusion, with the release rate governed by
DIA is used for a range of systemic medications with suitable lipophilicity and molecular size, including nicotine
Advantages of the DIA approach include straightforward manufacturing, thin and flexible patches, and sustained, predictable release
Manufacturing involves blending the drug with the adhesive, coating a thin film onto a patch backing, and